兽药残留是食品安全领域中尤为重要的检测项目，最常见的样品有组织样品、禽蛋、奶、尿液等等，但因兽药残留具有基质复杂、残留浓度低、目标物化合物性质差异大、检测限越来越严格等等特点，对于前处理技术更需要精准控制，才能保证结果准确性，其中在兽残领域，固相萃取是标准中最常见的前处理技术，所以在前处理中，仪器的稳定性和准确性，能取代人工误差，和时间、精力的解放，这点尤为重要。
本文以GB-31658.17-2021为例，介绍动物性食品中四环素类、磺胺类和喹诺酮类药物残留量的前处理解决方案，可采用Leowlab Purifier A48正压固相萃取仪实现低浓度残留基质的高效萃取，搭配Leowlab SmartVap AE全自动氮吹浓缩仪使用，无需样品转移，减少样品的损失。
[/fusion_text][fusion_builder_row_inner][fusion_builder_column_inner type=”1_3″ type=”1_3″ align_self=”auto” content_layout=”column” align_content=”flex-start” valign_content=”flex-start” content_wrap=”wrap” center_content=”no” column_tag=”div” target=”_self” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” order_medium=”0″ order_small=”0″ hover_type=”none” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ background_type=”single” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ lazy_load=”avada” background_position=”left top” background_repeat=”no-repeat” background_blend_mode=”none” background_slider_skip_lazy_loading=”no” background_slider_loop=”yes” background_slider_pause_on_hover=”no” background_slider_slideshow_speed=”5000″ background_slider_animation=”fade” background_slider_direction=”up” 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filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ image_id=”6065|fusion-400″ link=”https://leowlab.com/positive-pressure-solid-phase-extractor/purifier-a48/” caption_title=”Leowlab Purifier A48″ caption_text=”48位正压固相萃取仪” caption_title_transform=”capitalize” caption_text_transform=”capitalize” caption_overlay_color=”hsla(var(–awb-color7-h),var(–awb-color7-s),calc(var(–awb-color7-l) + 40%),var(–awb-color7-a))” fusion_font_variant_caption_title_font=”600″ fusion_font_family_caption_title_font=”Montserrat” caption_title_size=”16″ caption_title_color=”var(–awb-color1)” fusion_font_variant_caption_text_font=”400″ fusion_font_family_caption_text_font=”Montserrat” caption_text_size=”16″ caption_border_color=”var(–awb-color1)” caption_text_color=”var(–awb-color1)”]https://leowlab.com/wp-content/uploads/2025/10/A48-400×400.jpg[/fusion_imageframe][/fusion_builder_column_inner][fusion_builder_column_inner type=”1_3″ type=”1_3″ align_self=”auto” content_layout=”column” 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animation_delay=”0″ last=”no” border_position=”all”][fusion_imageframe custom_aspect_ratio=”100″ lightbox=”no” linktarget=”_blank” align_medium=”none” align_small=”none” align=”center” hover_type=”none” magnify_duration=”120″ scroll_height=”100″ scroll_speed=”1″ caption_style=”resa” caption_align_medium=”none” caption_align_small=”none” caption_align=”center” caption_title_tag=”div” animation_direction=”left” animation_speed=”0.3″ animation_delay=”0″ hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ image_id=”6069|fusion-400″ link=”https://leowlab.com/nitrogen-evaporator/smartvap-ae/” caption_title=”Leowlab SmartVap AE” caption_title_transform=”capitalize” caption_text_transform=”capitalize” caption_overlay_color=”hsla(var(–awb-color7-h),var(–awb-color7-s),calc(var(–awb-color7-l) + 40%),var(–awb-color7-a))” fusion_font_variant_caption_title_font=”600″ fusion_font_family_caption_title_font=”Montserrat” caption_title_size=”16″ caption_title_color=”var(–awb-color1)” fusion_font_variant_caption_text_font=”400″ fusion_font_family_caption_text_font=”Montserrat” caption_text_size=”16″ caption_border_color=”var(–awb-color1)” caption_text=”全自动氮吹浓缩仪”]https://leowlab.com/wp-content/uploads/2025/10/QE-AE-400×400.jpg[/fusion_imageframe][/fusion_builder_column_inner][fusion_builder_column_inner type=”1_3″ type=”1_3″ align_self=”auto” content_layout=”column” align_content=”flex-start” valign_content=”flex-start” content_wrap=”wrap” center_content=”no” column_tag=”div” target=”_self” 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align_medium=”none” align_small=”none” align=”center” hover_type=”none” magnify_duration=”120″ scroll_height=”100″ scroll_speed=”1″ caption_style=”resa” caption_align_medium=”none” caption_align_small=”none” caption_align=”center” caption_title_tag=”div” animation_direction=”left” animation_speed=”0.3″ animation_delay=”0″ hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ image_id=”6071|fusion-400″ link=”https://leowlab.com/nitrogen-generator/nitrogen-evaporator-1/clart-mp-series/” caption_title=”Leowlab NG-MP” caption_text=”氮吹用氮气发生器” caption_title_transform=”capitalize” caption_text_transform=”capitalize” caption_overlay_color=”hsla(var(–awb-color7-h),var(–awb-color7-s),calc(var(–awb-color7-l) + 40%),var(–awb-color7-a))” fusion_font_variant_caption_title_font=”600″ fusion_font_family_caption_title_font=”Montserrat” caption_title_size=”16″ caption_title_color=”var(–awb-color1)” fusion_font_variant_caption_text_font=”400″ fusion_font_family_caption_text_font=”Montserrat” caption_text_size=”16″ caption_border_color=”var(–awb-color1)”]https://leowlab.com/wp-content/uploads/2025/10/氮发-中-400×400.jpg[/fusion_imageframe][/fusion_builder_column_inner][/fusion_builder_row_inner][fusion_title title_type=”text” scroll_reveal_effect=”color_change” scroll_reveal_basis=”chars” scroll_reveal_behavior=”always” scroll_reveal_duration=”500″ scroll_reveal_stagger=”200″ scroll_reveal_delay=”0″ scroll_reveal_above_fold=”yes” marquee_direction=”left” marquee_mask_edges=”no” marquee_speed=”15000″ rotation_effect=”bounceIn” display_time=”1200″ highlight_effect=”circle” loop_animation=”once” highlight_animation_duration=”1500″ highlight_width=”9″ highlight_smudge_effect=”no” highlight_top_margin=”0″ title_link=”off” link_target=”_self” content_align=”left” size=”div” text_shadow=”no” text_shadow_blur=”0″ text_stroke=”no” text_stroke_size=”1″ text_overflow=”none” gradient_font=”no” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ style_type=”default” animation_direction=”left” animation_speed=”0.3″ animation_delay=”0″ hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” font_size=”30″ fusion_font_variant_title_font=”600″ fusion_font_family_title_font=”Montserrat” margin_bottom=”30px” margin_top=”30px”]仪器设备[/fusion_title][fusion_table fusion_table_type=”2″ fusion_table_rows=”4″ fusion_table_columns=”2″ animation_direction=”left” animation_speed=”0.3″ animation_delay=”0″ hide_on_mobile=”small-visibility,medium-visibility,large-visibility”]| 前处理仪器设备 | |
|---|---|
| 萃取仪 | Leowlab Purifier A48正压固相萃取仪 |
| 浓缩系统 | Leowlab SmartVap AE全自动氮吹浓缩仪 |
| 搭配浓缩系统仪器 | Leowlab NG-MP系列氮吹用氮气发生器 |
| 分析仪器 | |
|---|---|
| 液相色谱-串联质谱仪 | 配电喷雾离子源 |
前处理流程图
[/fusion_title][fusion_imageframe custom_aspect_ratio=”100″ lightbox=”no” linktarget=”_self” align_medium=”none” align_small=”none” align=”none” hover_type=”none” magnify_duration=”120″ scroll_height=”100″ scroll_speed=”1″ caption_style=”off” caption_align_medium=”none” caption_align_small=”none” caption_align=”none” caption_title_tag=”2″ animation_direction=”left” animation_speed=”0.3″ animation_delay=”0″ hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ image_id=”7441|full”]https://leowlab.com/wp-content/uploads/2026/01/兽残.png[/fusion_imageframe][fusion_title title_type=”text” scroll_reveal_effect=”color_change” scroll_reveal_basis=”chars” scroll_reveal_behavior=”always” scroll_reveal_duration=”500″ scroll_reveal_stagger=”200″ scroll_reveal_delay=”0″ scroll_reveal_above_fold=”yes” marquee_direction=”left” marquee_mask_edges=”no” marquee_speed=”15000″ rotation_effect=”bounceIn” display_time=”1200″ highlight_effect=”circle” loop_animation=”once” highlight_animation_duration=”1500″ highlight_width=”9″ highlight_smudge_effect=”no” highlight_top_margin=”0″ title_link=”off” link_target=”_self” content_align=”left” size=”div” text_shadow=”no” text_shadow_blur=”0″ text_stroke=”no” text_stroke_size=”1″ text_overflow=”none” gradient_font=”no” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ style_type=”default” animation_direction=”left” animation_speed=”0.3″ animation_delay=”0″ hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” font_size=”26″ fusion_font_variant_title_font=”600″ fusion_font_family_title_font=”Montserrat” margin_bottom=”30px” margin_top=”30px”]实验方法概要：
[/fusion_title][fusion_text animation_direction=”left” animation_speed=”0.3″ animation_delay=”0″ disable_idd=”no” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” fusion_font_variant_text_font=”400″ fusion_font_family_text_font=”Montserrat” columns=”1″]1、称取1g制备好的动物组织，加入Mcllvaine-Na,EDTA 缓冲液提取，离心，取上清液，残渣加磷酸盐缓冲液，合并提取液；
2、采用Leowlab Purifier A48正压固相萃取仪进行净化处理；
3、将（固相萃取仪配套的）过柱后的收集管直接放至Leowlab SmartVap AE全自动氮吹浓缩仪，45℃水浴，设置程序，自动氮吹近干。
4、用1.00ml复溶液（复溶液:取水40ml，加甲醇5ml、乙腈5ml、甲酸0.05ml，混匀。）复溶样品，涡旋混合，待上机。
[/fusion_text][fusion_title title_type=”text” scroll_reveal_effect=”color_change” scroll_reveal_basis=”chars” scroll_reveal_behavior=”always” scroll_reveal_duration=”500″ scroll_reveal_stagger=”200″ scroll_reveal_delay=”0″ scroll_reveal_above_fold=”yes” marquee_direction=”left” marquee_mask_edges=”no” marquee_speed=”15000″ rotation_effect=”bounceIn” display_time=”1200″ highlight_effect=”circle” loop_animation=”once” highlight_animation_duration=”1500″ highlight_width=”9″ highlight_smudge_effect=”no” highlight_top_margin=”0″ title_link=”off” link_target=”_self” content_align=”left” size=”div” text_shadow=”no” text_shadow_blur=”0″ text_stroke=”no” text_stroke_size=”1″ text_overflow=”none” gradient_font=”no” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ style_type=”default” animation_direction=”left” animation_speed=”0.3″ animation_delay=”0″ hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” font_size=”30″ fusion_font_variant_title_font=”600″ fusion_font_family_title_font=”Montserrat” margin_bottom=”30px” margin_top=”30px”]结论[/fusion_title][fusion_text animation_direction=”left” animation_speed=”0.3″ animation_delay=”0″ disable_idd=”no” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” fusion_font_variant_text_font=”400″ fusion_font_family_text_font=”Montserrat” columns=”1″]动物组织脂肪含量高，在前处理过程，利用半自动正压固相萃取仪代替负压萃取装置，大大减少前处理时间，样品均匀过柱，获得极佳的重复性和回收率。
[/fusion_text][fusion_title title_type=”text” scroll_reveal_effect=”color_change” scroll_reveal_basis=”chars” scroll_reveal_behavior=”always” scroll_reveal_duration=”500″ scroll_reveal_stagger=”200″ scroll_reveal_delay=”0″ scroll_reveal_above_fold=”yes” marquee_direction=”left” marquee_mask_edges=”no” marquee_speed=”15000″ rotation_effect=”bounceIn” display_time=”1200″ highlight_effect=”circle” loop_animation=”once” highlight_animation_duration=”1500″ highlight_width=”9″ highlight_smudge_effect=”no” highlight_top_margin=”0″ title_link=”off” link_target=”_self” content_align=”left” size=”div” text_shadow=”no” text_shadow_blur=”0″ text_stroke=”no” text_stroke_size=”1″ text_overflow=”none” gradient_font=”no” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ style_type=”default” animation_direction=”left” animation_speed=”0.3″ animation_delay=”0″ hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” font_size=”30″ fusion_font_variant_title_font=”600″ fusion_font_family_title_font=”Montserrat” margin_bottom=”30px” margin_top=”30px”]方案特点
[/fusion_title][fusion_text animation_direction=”left” animation_speed=”0.3″ animation_delay=”0″ disable_idd=”no” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” fusion_font_variant_text_font=”400″ fusion_font_family_text_font=”Montserrat” columns=”1″]1、 48个样同时过柱：Leowlab Purifier A48正压固相萃取仪可一次性同时处理48个样品，大大减少实验时间；
2、复杂基质，轻松过柱：针对脂肪含量高的动物组织，正压最大承受压力100psi,远超过负压，轻松更快过柱；
3、 很好的重复性和回收率：氮气作为气源，正压过柱，保证每个柱子压力均匀性，保证极佳的回收率；
4、 净化到浓缩收集管直接转移：全自动氮吹浓缩仪，接收管体积0-40mL，净化完的接收管可直接转移至Leowlab SmartVap AE全自动氮吹浓缩仪氮吹，减少样品在转移过程中的损失；
5、涡旋斜吹技术：Leowlab SmartVap AE采用涡旋剪切气流技术，样品浓缩快速、平和；
6、智能化浓缩：Leowlab SmartVap AE气流可自动控制，支持梯度自动控制，优化浓缩进程；
7、多种支架可供选择：Leowlab SmartVap AE适应不同直径不同高度的试管、离心管。
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